Caitlyn vs Kai'Sa ADC Matchup

How to play as Caitlyn

Bully Kai'Sa aggressively from levels 1 through 5 with your 125 range advantage: deny her farm and crash large waves to delay her Q-evolve power spike as long as possible.

When Kai'Sa dives, use 90 Caliber Net(E) to recoil away, then stay near minions or an ally so they can split Icathian Rain(Q)'s missiles. (Unverified: no source confirms this note.)

Caitlyn's 650 attack range outranges Kai'Sa's 525 attack range by 125 units, enabling heavy poke and zoning whenever Kai'Sa steps up to last hit.

90 Caliber Net (E) knocks Caitlyn backward while slowing the first enemy struck, allowing her to disengage from Kai'Sa's dive attempts while granting an empowered Headshot.

Killer Instinct(R) can target only a visible enemy champion marked with Plasma, and its range increases with Kai'Sa's rank.

How to play as Kai'Sa

Avoid extended early trades: practice buffering a basic attack and Icathian Rain (Q) simultaneously before immediately backing off, minimizing the free poke Caitlyn can return.

Hold Supercharge (E) defensively in lane to sidestep Piltover Peacemaker and support skillshots rather than burning it forward to chase poke.

Use Killer Instinct(R) only on a visible, Plasma-marked Caitlyn within your current rank's range; choose a landing point clear of her traps and net with an escape route.

Icathian Rain (Q) splits its missile swarm across all nearby enemies, dealing maximum burst damage only when Kai'Sa fights Caitlyn isolated away from the minion wave.

Sources

These notes come from r/kaisamains and LoL Wiki, checked against the champions' abilities.