Cassiopeia vs Malzahar Mid Matchup

Cassiopeia Mid wins 41.8% of 665 Low Elo games against Malzahar Mid, -1.0 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

How to play as Cassiopeia

Use Noxious Blast(Q) to remove Void Shift(P) before committing to Twin Fang(E); if Malzahar spends Call of the Void(Q) on the wave, Cass players identify that as a safer window to trade.

Keep Petrifying Gaze(R) ready if Malzahar starts Nether Grasp(R) in your range; Cass players recommend using its stun to interrupt his channel.

Void Shift(P) protects Malzahar until he takes damage or crowd control; Noxious Blast(Q) can break that protection, and a poisoned target takes increased damage from Twin Fang(E).

Sources

These notes come from r/CassiopeiaMains, checked against the champions' abilities.