Darius & Lissandra Synergy
Darius Top and Lissandra Mid win 50.8% of 2,996 Low Elo games together, +1.3 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why this duo works
Lissandra's reliable engage and crowd control hold targets in place, giving Darius time to build Hemorrhage stacks and land Noxian Guillotine(R). If he gets the takedown, its reset lets him keep chaining through the fight.
Playing the duo
Glacial Path(E) lets Lissandra enter a fight and Ring of Frost(W) roots nearby enemies; that lockdown gives Darius time to reach and stack Hemorrhage(P) on a target.
How to play as Darius
Follow Lissandra's engage onto the controlled target, build Hemorrhage stacks, then use Noxian Guillotine(R) when it will secure the first takedown and start your reset chain.
Noxian Guillotine(R) deals true damage and refreshes when it kills; Lissandra's W and R can hold a target still long enough for Darius to build toward that execute.
How to play as Lissandra
When Darius is ready to follow, use Glacial Path(E) to enter and lock a priority target with Ring of Frost(W) or Frozen Tomb(R); avoid spending every control effect before he can reach the fight.
Sources
These notes come from r/LissandraMains and r/Dariusmains, checked against the champions' abilities.