Dr. Mundo vs Yorick Top Matchup
Dr. Mundo Top wins 44.9% of 1,375 Low Elo games against Yorick Top, -3.8 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
How to play as Dr. Mundo
Aim Infected Bonesaw(Q) around Yorick's ghouls instead of throwing it through them, and use Blunt Force Trauma(E) to clear pets that reach you. If Dark Procession(W) closes around you, attack the wall immediately rather than spending time walking against it.
Dr. Mundo's passive blocks the first immobilizing effect, but Yorick's Dark Procession(W) is terrain rather than a standard stun; once caught inside, Mundo can attack the wall to clear an escape route.
Yorick's ghouls can intercept Infected Bonesaw(Q), while Dr. Mundo can use Blunt Force Trauma(E) to clear nearby ghouls when they get close.
How to play as Yorick
Use ghouls to screen Infected Bonesaw(Q), and set Dark Procession(W) across Mundo's escape path when you have enough summons to follow up. Your stronger early-mid window is the time to build pressure before his health scaling catches up.
Sources
These notes come from mobafire.com and r/DrMundoMains, checked against the champions' abilities.