Ekko vs Lissandra Mid Matchup
Ekko Mid wins 50.6% of 1,599 Low Elo games against Lissandra Mid, -0.2 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Lissandra is favored
Ekko's short trade depends on using E to get close and trigger his passive. If he commits into Lissandra's W range, she can root him and answer with autos and Q while his dash is unavailable. Disciplined Lissandra players can punish that entry instead of trading before he commits, which gives a clear reason for her +3.8 percentage-point HIGH ELO advantage.
Measured in High Elo: Lissandra wins 2.5pp more often than expected over 1,069 games.
How to play as Ekko
Use Q to farm when Lissandra still has W; if you use E to enter, be ready for her root and avoid extending the trade after your dash is spent.
When Ekko uses E to enter melee range, Lissandra's 450-range W can root him and let her answer with autos and Q while his dash is spent.
Ekko can use Q to farm and push without committing his short-range E trade, so Lissandra should distinguish a safe Q clear from an actual all-in.
How to play as Lissandra
Wait for Ekko to commit E before using W; root him, then follow with autos and Q while he has no dash to leave the trade.
Sources
These notes come from r/LissandraMains, checked against the champions' abilities.