Kai'Sa & Neeko Synergy

Kai'Sa ADC and Neeko Support win 51.0% of 3,466 Low Elo games together, +1.9 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

Why this duo works

Neeko's Tangle-Barbs(E) and Pop Blossom(R) immobilize targets, adding Plasma stacks for Kai'Sa. If the target remains visible and within Kai'Sa's current rank's Killer Instinct(R) range, that crowd control gives her an opening to join Neeko's engage.

Measured in High Elo: this duo wins 1.8pp more often than expected over 1,751 games.

Playing the duo

Tangle-Barbs(E) roots enemies and Pop Blossom(R) knocks up then stuns them; those allied immobilizations help Kai'Sa stack Plasma from Second Skin(P).

How to play as Kai'Sa

After Neeko's root or ultimate has applied Plasma, use Killer Instinct(R) only if the target remains visible and within your current rank's range; follow the controlled target from a landing angle that does not strand you in the enemy team.

How to play as Neeko

Approach from a flank or use Inherent Glamour(P) to hide Pop Blossom(R)'s preparation, and give Kai'Sa time to follow the knockup with her own entry.

Sources

These notes come from r/kaisamains and LoL Wiki, checked against the champions' abilities.