Kog'Maw ADC vs Thresh Support Matchup
Kog'Maw ADC wins 53.4% of 2,418 Low Elo games against Thresh Support, +1.2 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Kog'Maw is favored
Kog'Maw can punish Thresh when he cannot find a hook angle: Caustic Spittle(Q) and Void Ooze(E) reach slightly farther than Death Sentence(Q), and Void Ooze slows him while Kog keeps up ranged pressure. Thresh players note that long-range picks can stay beyond hook range and poke, while Kog players emphasize spacing with Bio-Arcane Barrage(W).
Measured in High Elo: Kog'Maw wins 1.4pp more often than expected over 1,265 games.
How to play as Kog'Maw
Keep minions between you and Thresh, use Void Ooze(E) to slow a walk-up, and save Bio-Arcane Barrage(W) for trades once Death Sentence(Q) is unavailable.
Do not walk forward to trade with W while Thresh's hook is ready; his extra attack range does not protect you from a long-range catch.
Caustic Spittle(Q) and Void Ooze(E) reach farther than Death Sentence(Q), and Void Ooze(E) leaves a slow zone that can make Thresh's approach costly.
How to play as Thresh
Look for a clear hook angle around the wave and commit when Kog'Maw has used Void Ooze(E); Kog mains warn that a landed hook from Thresh is often lethal because Kog has no mobility.
Kog'Maw has no dash, so a landed Death Sentence(Q) can pull him into Flay(E) and The Box(R) before he can reposition.
Sources
These notes come from r/ThreshMains and r/KogMawMains, checked against the champions' abilities.