Lillia & Vayne Synergy

Lillia Jungle and Vayne ADC win 54.0% of 1,862 Low Elo games together, +1.5 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

Why this duo works

Lillia's area sleep gives Vayne a clear target to follow up on, and waking that target triggers Lillia's bonus damage while Vayne continues her sustained attacks. The pair works best when Lillia's Dream Dust has landed before she casts her ultimate.

Playing the duo

Lilting Lullaby (R) only affects enemies already marked with Dream Dust when the cast resolves; once a target is asleep, Vayne's damage wakes it and triggers Lillia's wake-up damage.

Vayne's Silver Bolts (W) adds percentage max-health true damage on every third hit, giving her sustained follow-up after Lillia's sleep setup.

How to play as Lillia

Make sure Dream Dust has actually landed before casting Lilting Lullaby (R); an E seed that is still in flight will not mark its target in time.

How to play as Vayne

Let Lillia's sleep resolve before your first attack, then focus that target immediately to trigger the wake-up damage and continue your Silver Bolts (W) sequence.

Sources

These notes come from r/LilliaMains, checked against the champions' abilities.