Thresh Support vs Kai'Sa ADC Matchup
Thresh Support wins 51.9% of 17,686 Low Elo games against Kai'Sa ADC, +0.5 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
How to play as Thresh
Do not fish for max-range hooks through minion lines against mobile Kai'Sa; walk up from brush to lead with a Flay(E) slow, making the follow-up Death Sentence(Q) much easier to land.
Hold Death Sentence(Q) to maintain constant lane pressure; with Kai'Sa's short 525 basic attack range, the threat of your hook forces her to concede minion last hits or blow Supercharge(E) defensively.
Flay(E) is a directional displacement that interrupts dashes, which can halt Kai'Sa if timed as she dashes in with Killer Instinct(R).
How to play as Kai'Sa
Position diagonally across from Thresh and stay inside the minion wave; minion collision blocks Death Sentence(Q), and freezing just outside your turret denies him aggressive all-in angles.
Whenever Thresh whiffs a hook, immediately step up with your support to punish him or his marksman during his 19-second early cooldown window, looking for an isolated Icathian Rain(Q) trade.
Supercharge's(E) evolved invisibility breaks target acquisition and grants bonus move speed, allowing Kai'Sa to change direction unpredictably to dodge Death Sentence(Q) hooks.
Death Sentence(Q) has a 19-second cooldown at rank 1, leaving Thresh without his primary crowd control tool and vulnerable to Kai'Sa's isolated Icathian Rain(Q) burst when it misses.
Sources
These notes come from r/kaisamains, checked against the champions' abilities.