Twisted Fate & Pyke Synergy
Twisted Fate Mid and Pyke Support win 47.8% of 1,912 Low Elo games together, -0.1 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Playing the duo
Twisted Fate's Pick a Card(W) Gold Card is a targeted stun that can follow Pyke's Bone Skewer(Q) or Phantom Undertow(E), and Destiny(R) can bring him to Pyke's side-lane engages.
Pyke's Death From Below(R) can execute the low-health target after Twisted Fate's stun and burst, rewarding the team with a reset and bonus ally gold.
How to play as Twisted Fate
Cycle Pick a Card(W) early and hold Gold Card for Pyke's engage. Use Destiny(R) to join a Pyke roam or dive, then chain your stun after his hook or dash stun.
How to play as Pyke
Signal a mid or side-lane roam before committing; land Bone Skewer(Q) or Phantom Undertow(E) first so Twisted Fate can follow with a prepared Gold Card or Destiny(R).
Sources
These notes come from mobafire.com.