Vex & Pantheon Synergy
Vex Mid and Pantheon Support win 51.8% of 1,625 Low Elo games together, +0.9 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why this duo works
Pantheon's point-and-click Shield Vault(W) creates a reliable opening for Vex to follow with her empowered fear and burst. Vex can enter after Pantheon and use Shadow Surge(R) to extend the catch, matching the engage-and-cleanup pattern Vex players recommend for hard-CC partners.
Playing the duo
Shield Vault(W) gives Pantheon a targeted stun to start a pick, while Vex can follow with a primed Doom 'n Gloom(P) fear and Shadow Surge(R) damage; her ultimate can then be recast to join the fight.
How to play as Vex
Let Pantheon start the fight with Shield Vault(W); follow with a primed Doom 'n Gloom(P) fear and Mistral Bolt(Q) or Looming Darkness(E), then use Shadow Surge(R) to join or finish rather than taking the first risk.
How to play as Pantheon
Only commit with Shield Vault(W) when Vex can follow; her primed Doom 'n Gloom(P) fear and Shadow Surge(R) can extend the same pick, so avoid diving beyond her reach.
Sources
These notes come from r/VexMains and r/vexmains, checked against the champions' abilities.