Xerath vs Lissandra Mid Matchup
Xerath Mid wins 54.1% of 1,684 Low Elo games against Lissandra Mid, +1.7 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Xerath is favored
Xerath's longer-range Q and W let him harass and clear from outside Lissandra's ordinary trade range. Her E is the main way to close that gap, but Xerath can hold E to stun her as she commits. This forces her to spend lane time dodging poke or waiting for his stun, making safe engage and roam windows harder to create; that fits Xerath's +4.8 percentage-point edge in HIGH ELO.
Measured in High Elo: Xerath wins 3.1pp more often than expected over 1,071 games.
How to play as Xerath
Keep E ready when Lissandra has E available; use Q or W to pressure her while she is deciding whether to dodge or defend the wave.
Xerath's Q, W, and E reach farther than Lissandra's 725-range Q, so he can poke while keeping his stun available for her approach.
Lissandra's E is her main way to close distance, and Xerath's E can stun her if he holds it for that entry.
How to play as Lissandra
Stand off the minion wave and move unpredictably to make Xerath choose between hitting you and pushing; look to punish after he spends a spell, and use an early Q-E-Q skill order to contest the first push.
Sources
These notes come from r/LissandraMains, checked against the champions' abilities.