Zilean vs Seraphine Support Matchup
Zilean Support wins 52.5% of 1,834 Low Elo games against Seraphine Support, +1.1 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
How to play as Zilean
Use Time Warp(E) to slow Seraphine when she tries to retreat or speed an ally around her slow skillshots; double-bomb her when she is committed to a cast or caught by a gank.
Save Chronoshift(R) for the Seraphine target most likely to die rather than casting it early; she can force a difficult choice if Encore(R) catches more than one teammate.
Two Time Bomb(Q) casts on one target detonate the first early and stun; Seraphine's long spell cast animations can give Zilean time to set up that combo.
How to play as Seraphine
If a gank starts, dodge at least one Time Bomb(Q) so Zilean cannot double-bomb stun you; save Surround Sound(W) to soften a single bomb if you get tagged.
Look for an Encore(R) that reaches Zilean and another ally, so Chronoshift(R) cannot protect everyone caught in the follow-up.
Chronoshift(R) can save one ally from lethal damage, while Encore(R) can hit several champions, forcing Zilean to choose whom to protect.
Sources
These notes come from r/SeraphineMains, checked against the champions' abilities.