Annie & Ezreal Synergy
Annie Mid and Ezreal ADC win 45.7% of 1,594 Low Elo games together, -0.2 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Playing the duo
When Pyromania(P) is ready, Annie's next offensive spell can stun; her ultimate can give Ezreal a brief opening to follow with his own burst.
How to play as Annie
If Ezreal is ready to follow up, use Tibbers with Pyromania ready to create a short opening for him to land his burst.
How to play as Ezreal
Watch Annie's stun-ready cue and prepare to follow her Tibbers engage with Trueshot Barrage while the target is caught.
Sources
These notes come from r/ezrealmains, checked against the champions' abilities.