Best Cassiopeia ADC Synergies

The best Support with Cassiopeia ADC is Nautilus. The pair wins 51.0% across 1,086 games, 0.3 points more than the two champions' own win rates predict. Based on High Elo Ranked Solo/Duo games, patches 26.20-26.22. These are observed associations, not guaranteed outcomes. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Updated 2026-11-15. Data is current for LoL patch 26.22 (all regions, low elo and high elo).

Top 1 High Elo Cassiopeia ADC bot-lane duo synergies with Support

  1. Nautilus Support - 51.0% win rate with Cassiopeia ADC (+0.3 points vs expected), 1,086 games.

Top 1 High Elo Cassiopeia ADC all-role strongest synergies

  1. Nautilus Support - 51.0% win rate with Cassiopeia ADC (+0.3 points vs expected), 1,086 games.

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 1,000 games.

Read the full methodology for the model and guidance on interpreting these results.