Best Cassiopeia Mid Synergies

The best partner with Cassiopeia Mid is Yone Top. The pair wins 46.3% across 1,759 games, 0.7 points more than the two champions' own win rates predict. Sett Top (+0.7 over 1,568 games) and Pyke Support (+0.6 over 1,142 games) also over-perform. Sett Top has the highest raw win rate (49.7%) among well-sampled pairs, but that is about what its own strength predicts (47.0% expected). Based on Low Elo Ranked Solo/Duo games, patches 26.20-26.22. These are observed associations, not guaranteed outcomes. The weakest listed synergies for Cassiopeia Mid are Teemo Top, Mordekaiser Top, Malphite Top, Seraphine Support, Lux Support, Senna Support, Yunara ADC, Ashe ADC, Morgana Support, and Lulu Support. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Updated 2026-11-15. Data is current for LoL patch 26.22 (all regions, low elo and high elo).

Top 10 Low Elo Cassiopeia Mid all-role strongest synergies

  1. Yone Top - 46.3% win rate with Cassiopeia Mid (+0.7 points vs expected), 1,759 games.
  2. Sett Top - 49.7% win rate with Cassiopeia Mid (+0.7 points vs expected), 1,568 games.
  3. Pyke Support - 48.1% win rate with Cassiopeia Mid (+0.6 points vs expected), 1,142 games.
  4. Darius Top - 46.5% win rate with Cassiopeia Mid (+0.6 points vs expected), 1,763 games.
  5. Lucian ADC - 46.1% win rate with Cassiopeia Mid (+0.6 points vs expected), 1,422 games.
  6. Renekton Top - 49.4% win rate with Cassiopeia Mid (+0.4 points vs expected), 1,120 games.
  7. Leona Support - 49.4% win rate with Cassiopeia Mid (+0.4 points vs expected), 2,025 games.
  8. Tristana ADC - 47.0% win rate with Cassiopeia Mid (+0.4 points vs expected), 1,740 games.
  9. Twitch ADC - 48.6% win rate with Cassiopeia Mid (+0.4 points vs expected), 1,047 games.
  10. Blitzcrank Support - 48.1% win rate with Cassiopeia Mid (+0.4 points vs expected), 1,423 games.

Top 10 Low Elo Cassiopeia Mid all-role weakest synergies

  1. Teemo Top - 44.0% win rate with Cassiopeia Mid (-1.0 points vs expected), 1,244 games.
  2. Mordekaiser Top - 46.9% win rate with Cassiopeia Mid (-0.7 points vs expected), 1,382 games.
  3. Malphite Top - 47.0% win rate with Cassiopeia Mid (-0.5 points vs expected), 1,339 games.
  4. Seraphine Support - 44.4% win rate with Cassiopeia Mid (-0.5 points vs expected), 1,878 games.
  5. Lux Support - 45.9% win rate with Cassiopeia Mid (-0.4 points vs expected), 2,391 games.
  6. Senna Support - 47.1% win rate with Cassiopeia Mid (-0.3 points vs expected), 1,021 games.
  7. Yunara ADC - 43.4% win rate with Cassiopeia Mid (-0.3 points vs expected), 1,891 games.
  8. Ashe ADC - 43.9% win rate with Cassiopeia Mid (-0.3 points vs expected), 1,741 games.
  9. Morgana Support - 43.5% win rate with Cassiopeia Mid (-0.2 points vs expected), 1,413 games.
  10. Lulu Support - 45.7% win rate with Cassiopeia Mid (-0.2 points vs expected), 1,836 games.

Top 10 High Elo Cassiopeia Mid all-role strongest synergies

  1. Pyke Support - 49.2% win rate with Cassiopeia Mid (+1.0 points vs expected), 1,011 games.
  2. Nautilus Support - 48.4% win rate with Cassiopeia Mid (+0.7 points vs expected), 2,092 games.
  3. Blitzcrank Support - 51.9% win rate with Cassiopeia Mid (+0.7 points vs expected), 1,293 games.
  4. Leona Support - 51.8% win rate with Cassiopeia Mid (+0.6 points vs expected), 1,266 games.
  5. Tristana ADC - 49.5% win rate with Cassiopeia Mid (+0.4 points vs expected), 1,447 games.
  6. Kai'Sa ADC - 49.2% win rate with Cassiopeia Mid (+0.4 points vs expected), 3,511 games.
  7. Thresh Support - 51.3% win rate with Cassiopeia Mid (+0.3 points vs expected), 2,478 games.
  8. Renekton Top - 51.4% win rate with Cassiopeia Mid (+0.2 points vs expected), 1,032 games.
  9. Jhin ADC - 48.3% win rate with Cassiopeia Mid (+0.2 points vs expected), 3,314 games.
  10. Aphelios ADC - 48.1% win rate with Cassiopeia Mid (+0.2 points vs expected), 1,434 games.

Top 10 High Elo Cassiopeia Mid all-role weakest synergies

  1. Lulu Support - 48.5% win rate with Cassiopeia Mid (-0.6 points vs expected), 2,365 games.
  2. Karma Support - 46.3% win rate with Cassiopeia Mid (-0.4 points vs expected), 1,393 games.
  3. Nami Support - 48.1% win rate with Cassiopeia Mid (-0.4 points vs expected), 1,367 games.
  4. Graves Jungle - 45.8% win rate with Cassiopeia Mid (-0.2 points vs expected), 1,436 games.
  5. Milio Support - 46.0% win rate with Cassiopeia Mid (-0.2 points vs expected), 1,086 games.
  6. Jinx ADC - 47.9% win rate with Cassiopeia Mid (-0.2 points vs expected), 1,992 games.
  7. Kha'Zix Jungle - 47.5% win rate with Cassiopeia Mid (-0.1 points vs expected), 1,279 games.
  8. Talon Jungle - 48.3% win rate with Cassiopeia Mid (-0.1 points vs expected), 1,272 games.
  9. Viego Jungle - 47.6% win rate with Cassiopeia Mid (-0.1 points vs expected), 1,295 games.
  10. Malphite Top - 49.8% win rate with Cassiopeia Mid (-0.1 points vs expected), 1,044 games.

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 1,000 games.

Read the full methodology for the model and guidance on interpreting these results.