Fizz & Vayne Synergy

Fizz Mid and Vayne ADC win 53.4% of 2,758 Low Elo games together, +1.7 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

Why this duo works

Chum the Waters (Fizz R) slows and then knocks up its target, giving Vayne (Vayne W) a brief, more predictable window to stack Silver Bolts. Vayne's sustained physical damage also complements Fizz's magic burst when they focus the same target.

Playing the duo

Fizz R slows and knocks up its target, while Vayne W adds true damage on her third consecutive hit; the crowd control can help Vayne keep attacks on the same target.

How to play as Fizz

Aim Fizz R at a target Vayne can already reach; its slow and delayed knock-up give her a clearer window to keep attacking.

How to play as Vayne

Follow the target Fizz catches with Fizz R, and save Vayne E until the shark's knock-up ends if Condemn can pin that target against terrain.

Sources

These notes come from winrate.gg and LoL Wiki, checked against the champions' abilities.