Gwen vs Mordekaiser Top Matchup
Gwen Top wins 49.6% of 2,080 Low Elo games against Mordekaiser Top, +1.5 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Gwen is favored
Gwen can sidestep the slow skillshots Mordekaiser needs to establish an extended trade, then punish with true damage from Snip Snip! (Q) and her health-scaling passive. Hallowed Mist (W) can also deny Realm of Death (R) when Mordekaiser casts from outside the mist.
How to play as Gwen
Keep Skip 'n Slash (E) to dodge Obliterate (Q) or Death's Grasp (E), then use short trades with the center of Snip Snip! (Q) and back off if Darkness Rise (P) activates. If Mordekaiser starts Realm of Death (R) from outside your mist, cast Hallowed Mist (W) during the cast.
Skip 'n Slash (E) can dodge Mordekaiser's slow Obliterate (Q) or Death's Grasp (E), denying the hits he needs to start Darkness Rise (P).
If Mordekaiser casts Realm of Death (R) from outside Hallowed Mist (W), Gwen can time the mist to become untargetable and deny the cast; this does not protect her if he is already inside the mist.
How to play as Mordekaiser
Do not waste Realm of Death (R) while Gwen is inside Hallowed Mist (W) or before she has spent it. Save Death's Grasp (E) until she uses Skip 'n Slash (E), then use the opening to stay close and extend the trade.
Sources
These notes come from r/GwenMains, Mobalytics, and mobafire.com.