Kai'Sa vs Zeri ADC Matchup

Kai'Sa ADC wins 48.2% of 4,764 Low Elo games against Zeri ADC, -0.3 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

How to play as Kai'Sa

Look for short burst trades rather than extended fights, where Zeri can use her mobility to kite you. (Unverified: no source confirms this note.)

Save E to avoid Zeri's Q or W, then use your burst when she has spent a key spell instead of trading repeatedly through her movement. (Unverified: no source confirms this note.)

Kai'Sa can use E to sidestep Zeri's Q and W, but Zeri's mobility makes extended chases difficult. (Unverified: no source confirms this note.)

Sources

These notes come from r/kaisamains.