Best Karthus Synergies

Use RiftMind to compare Karthus synergies, weak synergy partners, duo win rates, synergy deltas, sample sizes, and role-specific partner picks for low and high Elo League of Legends team comps.

Updated 2026-09-20. Data is current for LoL patch 26.18 (all regions, low elo and high elo).

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 500 games.

Read the full methodology for the model and guidance on interpreting these results.

Summary

Low Elo data lists Lulu Support, Fizz Mid, Samira ADC, Pyke Support, Zed Mid, Malphite Top, Blitzcrank Support, Aatrox Top, Leona Support, and Miss Fortune ADC as the strongest synergy partners for Karthus. The weakest listed synergies for Karthus are Veigar Mid, Gangplank Top, Ezreal ADC, Lux Support, Renekton Top, Nasus Top, Morgana Support, Seraphine Support, Tristana ADC, and Sylas Mid. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Detailed info:

Top 10 Low Elo Karthus strongest synergies

  1. Lulu Support - Low Elo data: Karthus Jungle vs Lulu Support, 53.5% observed win rate, +4.4 percentage points vs expected, 718 games, 3-patch window 26.16-26.18.
  2. Fizz Mid - Low Elo data: Karthus Jungle vs Fizz Mid, 55.2% observed win rate, +4.1 percentage points vs expected, 560 games, 3-patch window 26.16-26.18.
  3. Samira ADC - Low Elo data: Karthus Jungle vs Samira ADC, 52.5% observed win rate, +3.9 percentage points vs expected, 528 games, 3-patch window 26.16-26.18.
  4. Pyke Support - Low Elo data: Karthus Jungle vs Pyke Support, 51.0% observed win rate, +3.8 percentage points vs expected, 692 games, 3-patch window 26.16-26.18.
  5. Zed Mid - Low Elo data: Karthus Jungle vs Zed Mid, 51.9% observed win rate, +3.8 percentage points vs expected, 1,346 games, 3-patch window 26.16-26.18.
  6. Malphite Top - Low Elo data: Karthus Jungle vs Malphite Top, 53.9% observed win rate, +3.3 percentage points vs expected, 653 games, 3-patch window 26.16-26.18.
  7. Blitzcrank Support - Low Elo data: Karthus Jungle vs Blitzcrank Support, 52.4% observed win rate, +2.8 percentage points vs expected, 639 games, 3-patch window 26.16-26.18.
  8. Aatrox Top - Low Elo data: Karthus Jungle vs Aatrox Top, 51.4% observed win rate, +2.7 percentage points vs expected, 590 games, 3-patch window 26.16-26.18.
  9. Leona Support - Low Elo data: Karthus Jungle vs Leona Support, 53.0% observed win rate, +2.3 percentage points vs expected, 1,006 games, 3-patch window 26.16-26.18.
  10. Miss Fortune ADC - Low Elo data: Karthus Jungle vs Miss Fortune ADC, 51.4% observed win rate, +2.1 percentage points vs expected, 1,338 games, 3-patch window 26.16-26.18.

Top 10 Low Elo Karthus weakest synergies

  1. Veigar Mid - Low Elo data: Karthus Jungle vs Veigar Mid, 45.9% observed win rate, -4.7 percentage points vs expected, 536 games, 3-patch window 26.16-26.18.
  2. Gangplank Top - Low Elo data: Karthus Jungle vs Gangplank Top, 44.8% observed win rate, -4.1 percentage points vs expected, 507 games, 3-patch window 26.16-26.18.
  3. Ezreal ADC - Low Elo data: Karthus Jungle vs Ezreal ADC, 41.5% observed win rate, -3.8 percentage points vs expected, 1,124 games, 3-patch window 26.16-26.18.
  4. Lux Support - Low Elo data: Karthus Jungle vs Lux Support, 46.4% observed win rate, -2.4 percentage points vs expected, 1,083 games, 3-patch window 26.16-26.18.
  5. Renekton Top - Low Elo data: Karthus Jungle vs Renekton Top, 46.9% observed win rate, -2.3 percentage points vs expected, 512 games, 3-patch window 26.16-26.18.
  6. Nasus Top - Low Elo data: Karthus Jungle vs Nasus Top, 49.3% observed win rate, -2.1 percentage points vs expected, 1,108 games, 3-patch window 26.16-26.18.
  7. Morgana Support - Low Elo data: Karthus Jungle vs Morgana Support, 48.0% observed win rate, -2.0 percentage points vs expected, 725 games, 3-patch window 26.16-26.18.
  8. Seraphine Support - Low Elo data: Karthus Jungle vs Seraphine Support, 48.3% observed win rate, -1.9 percentage points vs expected, 1,049 games, 3-patch window 26.16-26.18.
  9. Tristana ADC - Low Elo data: Karthus Jungle vs Tristana ADC, 47.5% observed win rate, -1.8 percentage points vs expected, 995 games, 3-patch window 26.16-26.18.
  10. Sylas Mid - Low Elo data: Karthus Jungle vs Sylas Mid, 46.3% observed win rate, -1.8 percentage points vs expected, 505 games, 3-patch window 26.16-26.18.

Top 10 High Elo Karthus strongest synergies

  1. Qiyana Mid - High Elo data: Karthus Jungle vs Qiyana Mid, 56.5% observed win rate, +4.9 percentage points vs expected, 508 games, 3-patch window 26.16-26.18.
  2. Jhin ADC - High Elo data: Karthus Jungle vs Jhin ADC, 53.7% observed win rate, +4.4 percentage points vs expected, 1,202 games, 3-patch window 26.16-26.18.
  3. Graves Jungle - High Elo data: Karthus ADC vs Graves Jungle, 57.9% observed win rate, +3.9 percentage points vs expected, 556 games, 3-patch window 26.16-26.18.
  4. Aatrox Top - High Elo data: Karthus Jungle vs Aatrox Top, 52.9% observed win rate, +3.2 percentage points vs expected, 558 games, 3-patch window 26.16-26.18.
  5. Yasuo Mid - High Elo data: Karthus ADC vs Yasuo Mid, 56.5% observed win rate, +3.2 percentage points vs expected, 520 games, 3-patch window 26.16-26.18.
  6. Zed Mid - High Elo data: Karthus Jungle vs Zed Mid, 52.9% observed win rate, +2.5 percentage points vs expected, 1,294 games, 3-patch window 26.16-26.18.
  7. Lulu Support - High Elo data: Karthus Jungle vs Lulu Support, 52.8% observed win rate, +2.5 percentage points vs expected, 987 games, 3-patch window 26.16-26.18.
  8. Nautilus Support - High Elo data: Karthus Jungle vs Nautilus Support, 52.6% observed win rate, +2.5 percentage points vs expected, 989 games, 3-patch window 26.16-26.18.
  9. Yone Mid - High Elo data: Karthus Jungle vs Yone Mid, 51.5% observed win rate, +2.2 percentage points vs expected, 954 games, 3-patch window 26.16-26.18.
  10. Yunara ADC - High Elo data: Karthus Jungle vs Yunara ADC, 52.7% observed win rate, +2.0 percentage points vs expected, 855 games, 3-patch window 26.16-26.18.

Top 10 High Elo Karthus weakest synergies

  1. Milio Support - High Elo data: Karthus Jungle vs Milio Support, 47.1% observed win rate, -3.1 percentage points vs expected, 535 games, 3-patch window 26.16-26.18.
  2. Thresh Support - High Elo data: Karthus Jungle vs Thresh Support, 49.6% observed win rate, -2.6 percentage points vs expected, 1,091 games, 3-patch window 26.16-26.18.
  3. Seraphine Support - High Elo data: Karthus Jungle vs Seraphine Support, 48.4% observed win rate, -2.3 percentage points vs expected, 517 games, 3-patch window 26.16-26.18.
  4. Jinx ADC - High Elo data: Karthus Jungle vs Jinx ADC, 50.3% observed win rate, -1.9 percentage points vs expected, 1,128 games, 3-patch window 26.16-26.18.
  5. Leona Support - High Elo data: Karthus ADC vs Leona Support, 54.7% observed win rate, -1.2 percentage points vs expected, 601 games, 3-patch window 26.16-26.18.
  6. Yone Top - High Elo data: Karthus Jungle vs Yone Top, 49.2% observed win rate, -1.0 percentage points vs expected, 599 games, 3-patch window 26.16-26.18.
  7. Pyke Support - High Elo data: Karthus Jungle vs Pyke Support, 48.5% observed win rate, -0.9 percentage points vs expected, 517 games, 3-patch window 26.16-26.18.
  8. Tristana ADC - High Elo data: Karthus Jungle vs Tristana ADC, 51.3% observed win rate, -0.8 percentage points vs expected, 745 games, 3-patch window 26.16-26.18.
  9. Nami Support - High Elo data: Karthus Jungle vs Nami Support, 49.7% observed win rate, -0.8 percentage points vs expected, 811 games, 3-patch window 26.16-26.18.
  10. Nasus Top - High Elo data: Karthus Jungle vs Nasus Top, 50.4% observed win rate, -0.8 percentage points vs expected, 613 games, 3-patch window 26.16-26.18.