Kassadin vs Mel Mid Matchup
Kassadin Mid wins 55.6% of 642 Low Elo games against Mel Mid, +0.7 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
How to play as Kassadin
Prioritize surviving the early levels over forcing trades: use Null Sphere(Q) to mitigate poke and avoid Mel's Solar Snare(E), then begin trading once Riftwalk(R) gives you more room to reposition.
After level 6, use short Riftwalk(R) and Force Pulse(E) trades rather than staying in Mel's range; Kassadin players recommend pressing the advantage once he can move in and out, then taking his stronger side-lane scaling.
Null Sphere(Q) grants Kassadin a temporary magic-damage shield, and Kassadin players recommend using it to blunt Mel's spell poke.
Sources
These notes come from r/KassadinMains, checked against the champions' abilities.