Miss Fortune vs Ezreal ADC Matchup
Miss Fortune ADC wins 52.6% of 10,881 Low Elo games against Ezreal ADC, -1.2 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Ezreal is favored
Arcane Shift(E) lets Ezreal blink out of Bullet Time(R)'s cone when Miss Fortune commits to her channel, denying her main burst window. Miss Fortune mains specifically advise tracking Ezreal's blink and waiting until it is down before looking to punish him.
Measured in High Elo: Ezreal wins 1.7pp more often than expected over 2,653 games.
How to play as Miss Fortune
Save Bullet Time(R) while Ezreal still has Arcane Shift(E); look to channel after he spends the blink or when an ally has him locked down.
Use Make It Rain(E) to punish Ezreal when he steps forward or his Arcane Shift(E) is down, and keep enough space to avoid repeated Mystic Shot(Q) poke.
Ezreal's Arcane Shift(E) can blink him out of Bullet Time(R)'s cone, so the blink cooldown affects when Miss Fortune can safely channel at him.
How to play as Ezreal
Farm and poke with Mystic Shot(Q) from range, keeping Arcane Shift(E) for Miss Fortune's Bullet Time(R); if you spend the blink to poke forward, her slow or an ally's crowd control can punish the landing.
Sources
These notes come from r/MissFortuneMains, checked against the champions' abilities.