Miss Fortune ADC vs Nautilus Support Matchup
Miss Fortune ADC wins 52.4% of 10,627 Low Elo games against Nautilus Support, +1.5 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
How to play as Miss Fortune
Keep minions between you and Nautilus to block Dredge Line(Q); if he misses it, punish while it is on cooldown.
Hold Bullet Time(R) until Nautilus has spent Depth Charge(R) or committed it to someone else; its knock-up and stun can end your channel.
Nautilus's Dredge Line(Q) is blocked by minions, while his Depth Charge(R) can stop Miss Fortune's Bullet Time(R) with its knock-up and stun.
Sources
These notes come from r/JhinMains and r/MissFortuneMains, checked against the champions' abilities.