Best Seraphine Synergies

The best partner with Seraphine is Ashe ADC. The pair wins 52.4% across 58,987 games, 1.7 points more than the two champions' own win rates predict. Yasuo ADC (+1.2 over 2,090 games) and Warwick Jungle (+1.1 over 10,903 games) also over-perform. Maokai Jungle has the highest raw win rate (56.4%) among well-sampled pairs, but that is about what its own strength predicts (52.8% expected). Based on Low Elo Ranked Solo/Duo games, patches 26.20-26.22. These are observed associations, not guaranteed outcomes. The weakest listed synergies for Seraphine are Ziggs ADC, FiddleSticks Jungle, Taliyah Jungle, Samira ADC, Gangplank Top, Lucian ADC, Zyra Jungle, Hwei Mid, Lillia Jungle, and Lux Support. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Updated 2026-11-15. Data is current for LoL patch 26.22 (all regions, low elo and high elo).

Top 10 Low Elo Seraphine strongest synergies

  1. Ashe ADC - 52.4% win rate with Seraphine Support (+1.7 points vs expected), 58,987 games.
  2. Yasuo ADC - 55.6% win rate with Seraphine Support (+1.2 points vs expected), 2,090 games.
  3. Warwick Jungle - 54.8% win rate with Seraphine Support (+1.1 points vs expected), 10,903 games.
  4. Vayne ADC - 51.8% win rate with Seraphine Support (+1.1 points vs expected), 6,639 games.
  5. Maokai Jungle - 56.4% win rate with Seraphine Support (+0.9 points vs expected), 1,074 games.
  6. Irelia Mid - 53.0% win rate with Seraphine Support (+0.9 points vs expected), 5,347 games.
  7. Ezreal ADC - 48.6% win rate with Seraphine Support (+0.8 points vs expected), 21,423 games.
  8. Rammus Jungle - 53.7% win rate with Seraphine Support (+0.8 points vs expected), 4,958 games.
  9. Sejuani Jungle - 54.3% win rate with Seraphine Support (+0.7 points vs expected), 4,728 games.
  10. Tryndamere Jungle - 54.6% win rate with Seraphine Support (+0.7 points vs expected), 1,428 games.

Top 10 Low Elo Seraphine weakest synergies

  1. Ziggs ADC - 50.0% win rate with Seraphine Support (-1.9 points vs expected), 3,113 games.
  2. FiddleSticks Jungle - 50.0% win rate with Seraphine Support (-1.4 points vs expected), 3,213 games.
  3. Taliyah Jungle - 48.3% win rate with Seraphine Support (-1.4 points vs expected), 1,433 games.
  4. Samira ADC - 49.7% win rate with Seraphine Support (-1.4 points vs expected), 4,697 games.
  5. Gangplank Top - 49.6% win rate with Seraphine Support (-1.4 points vs expected), 7,165 games.
  6. Lucian ADC - 47.8% win rate with Seraphine Support (-1.3 points vs expected), 6,680 games.
  7. Zyra Jungle - 52.4% win rate with Seraphine Support (-1.2 points vs expected), 2,380 games.
  8. Hwei Mid - 50.3% win rate with Seraphine Support (-1.2 points vs expected), 6,071 games.
  9. Lillia Jungle - 52.9% win rate with Seraphine Support (-1.1 points vs expected), 9,446 games.
  10. Lux Support - 49.2% win rate with Seraphine ADC (-1.1 points vs expected), 1,174 games.

Top 10 High Elo Seraphine strongest synergies

  1. Vayne ADC - 52.1% win rate with Seraphine Support (+2.2 points vs expected), 1,669 games.
  2. Ashe ADC - 52.0% win rate with Seraphine Support (+2.1 points vs expected), 30,855 games.
  3. Rammus Jungle - 55.5% win rate with Seraphine Support (+1.9 points vs expected), 1,100 games.
  4. Yasuo Mid - 53.4% win rate with Seraphine ADC (+1.6 points vs expected), 1,024 games.
  5. Tristana ADC - 51.9% win rate with Seraphine Support (+1.2 points vs expected), 3,325 games.
  6. Nunu & Willump Jungle - 50.3% win rate with Seraphine Support (+1.0 points vs expected), 1,391 games.
  7. Ezreal ADC - 47.6% win rate with Seraphine Support (+0.9 points vs expected), 10,636 games.
  8. Yone Mid - 52.6% win rate with Seraphine ADC (+0.9 points vs expected), 1,039 games.
  9. Rek'Sai Jungle - 55.7% win rate with Seraphine Support (+0.9 points vs expected), 1,324 games.
  10. Amumu Jungle - 50.7% win rate with Seraphine Support (+0.8 points vs expected), 1,029 games.

Top 10 High Elo Seraphine weakest synergies

  1. Gangplank Top - 48.9% win rate with Seraphine Support (-2.4 points vs expected), 3,684 games.
  2. Taliyah Jungle - 52.3% win rate with Seraphine Support (-2.2 points vs expected), 1,459 games.
  3. Zyra Jungle - 49.7% win rate with Seraphine Support (-1.8 points vs expected), 1,102 games.
  4. Samira ADC - 48.4% win rate with Seraphine Support (-1.7 points vs expected), 1,021 games.
  5. Lux ADC - 47.9% win rate with Seraphine Support (-1.6 points vs expected), 1,440 games.
  6. Miss Fortune ADC - 48.5% win rate with Seraphine Support (-1.5 points vs expected), 6,536 games.
  7. Nidalee Jungle - 50.4% win rate with Seraphine Support (-1.5 points vs expected), 2,001 games.
  8. Sion Top - 49.8% win rate with Seraphine Support (-1.5 points vs expected), 2,634 games.
  9. Ziggs ADC - 47.8% win rate with Seraphine Support (-1.4 points vs expected), 1,135 games.
  10. Graves Jungle - 48.5% win rate with Seraphine Support (-1.2 points vs expected), 6,016 games.

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 1,000 games.

Read the full methodology for the model and guidance on interpreting these results.