Sett & Annie Synergy
Sett Top and Annie Mid win 54.7% of 1,189 Low Elo games together, +1.5 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why this duo works
Annie can speed Sett into The Show Stopper(R) with Molten Shield(E), then follow his landing with a ready Pyromania(P) stun from Tibbers(R). That layered catch gives Sett time to add Facebreaker(E) and Haymaker(W) while the enemies are still controlled.
Playing the duo
Molten Shield(E) can give Sett a movement-speed burst for his engage, and a Sett player recommends Annie following his Show Stopper(R) landing with Tibbers(R) while her charged Pyromania(P) stun is ready.
How to play as Sett
Before throwing a frontliner into the backline, check that Annie has Pyromania(P) ready and enough distance to follow; this gives her a chance to stun the landing area with Tibbers(R) while you use Facebreaker(E) and Haymaker(W).
How to play as Annie
Have Pyromania(P) ready before Sett engages. Use Molten Shield(E) on him as he advances, then cast Tibbers(R) around his Show Stopper(R) landing to stun enemies while Sett follows with Facebreaker(E).
Sources
These notes come from r/leagueoflegends, checked against the champions' abilities.