Syndra vs Ryze Mid Matchup
Syndra Mid wins 58.6% of 1,006 Low Elo games against Ryze Mid, +2.6 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Syndra is favored
Syndra's longer Q and W reach lets her harass Ryze before he can use his shorter-range W and E, while Q-E threatens him when he steps forward. Ryze players recommend clearing waves and roaming instead of forcing trades into that pressure, leaving Syndra in control of the lane.
How to play as Syndra
Use Q and W to pressure Ryze as he approaches the wave, and keep E available if he steps forward to trade; Ryze players describe the range and stun threat as difficult to answer directly.
Scatter the Weak(E) stuns Ryze only when it hits a Dark Sphere, so Syndra's stun threat drops after she spends E.
Dark Sphere(Q) reaches farther than Ryze's Rune Prison(W) and Spell Flux(E), letting Syndra poke him as he approaches the wave before he can answer with those spells.
How to play as Ryze
Focus on farming and clearing the wave instead of forcing trades into Syndra's range; look to move with your jungler when you have pushed the wave.
If Syndra spends Scatter the Weak(E) while you are near your tower, use the cooldown window to run her down only when the wave and your health let you follow safely.
Sources
These notes come from r/RyzeMains and r/syndramains, checked against the champions' abilities.