Best Vayne Synergies

Use RiftMind to compare Vayne synergies, weak synergy partners, duo win rates, synergy deltas, sample sizes, and role-specific partner picks for low and high Elo League of Legends team comps.

Updated 2026-09-20. Data is current for LoL patch 26.18 (all regions, low elo and high elo).

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 500 games.

Read the full methodology for the model and guidance on interpreting these results.

Summary

Low Elo data lists Malphite Jungle, Milio Support, Camille Support, Cho'Gath Jungle, Cassiopeia Mid, Veigar ADC, Twisted Fate Mid, Zilean Support, Ziggs ADC, and Sivir ADC as the strongest synergy partners for Vayne. The weakest listed synergies for Vayne are Aphelios ADC, Tahm Kench Support, Ashe Support, K'Sante Top, Hwei Mid, Karma Support, Qiyana Mid, Pantheon Top, Viego Jungle, and Gwen Mid. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Detailed info:

Top 10 Low Elo Vayne strongest synergies

  1. Malphite Jungle - Low Elo data: Vayne ADC vs Malphite Jungle, 54.2% observed win rate, +6.1 percentage points vs expected, 522 games, 3-patch window 26.16-26.18.
  2. Milio Support - Low Elo data: Vayne Top vs Milio Support, 55.2% observed win rate, +5.2 percentage points vs expected, 863 games, 3-patch window 26.16-26.18.
  3. Camille Support - Low Elo data: Vayne Top vs Camille Support, 48.4% observed win rate, +4.6 percentage points vs expected, 550 games, 3-patch window 26.16-26.18.
  4. Cho'Gath Jungle - Low Elo data: Vayne Top vs Cho'Gath Jungle, 54.9% observed win rate, +4.0 percentage points vs expected, 576 games, 3-patch window 26.16-26.18.
  5. Cassiopeia Mid - Low Elo data: Vayne ADC vs Cassiopeia Mid, 49.8% observed win rate, +3.9 percentage points vs expected, 500 games, 3-patch window 26.16-26.18.
  6. Veigar ADC - Low Elo data: Vayne Top vs Veigar ADC, 54.5% observed win rate, +3.8 percentage points vs expected, 639 games, 3-patch window 26.16-26.18.
  7. Twisted Fate Mid - Low Elo data: Vayne ADC vs Twisted Fate Mid, 52.0% observed win rate, +3.4 percentage points vs expected, 1,292 games, 3-patch window 26.16-26.18.
  8. Zilean Support - Low Elo data: Vayne ADC vs Zilean Support, 53.6% observed win rate, +3.4 percentage points vs expected, 1,089 games, 3-patch window 26.16-26.18.
  9. Ziggs ADC - Low Elo data: Vayne Top vs Ziggs ADC, 53.1% observed win rate, +3.2 percentage points vs expected, 799 games, 3-patch window 26.16-26.18.
  10. Sivir ADC - Low Elo data: Vayne Top vs Sivir ADC, 51.5% observed win rate, +3.1 percentage points vs expected, 687 games, 3-patch window 26.16-26.18.

Top 10 Low Elo Vayne weakest synergies

  1. Aphelios ADC - Low Elo data: Vayne Top vs Aphelios ADC, 43.4% observed win rate, -4.0 percentage points vs expected, 647 games, 3-patch window 26.16-26.18.
  2. Tahm Kench Support - Low Elo data: Vayne ADC vs Tahm Kench Support, 44.3% observed win rate, -3.9 percentage points vs expected, 1,508 games, 3-patch window 26.16-26.18.
  3. Ashe Support - Low Elo data: Vayne ADC vs Ashe Support, 41.2% observed win rate, -3.9 percentage points vs expected, 517 games, 3-patch window 26.16-26.18.
  4. K'Sante Top - Low Elo data: Vayne ADC vs K'Sante Top, 40.5% observed win rate, -3.7 percentage points vs expected, 857 games, 3-patch window 26.16-26.18.
  5. Hwei Mid - Low Elo data: Vayne Top vs Hwei Mid, 45.6% observed win rate, -3.6 percentage points vs expected, 607 games, 3-patch window 26.16-26.18.
  6. Karma Support - Low Elo data: Vayne Top vs Karma Support, 43.9% observed win rate, -3.4 percentage points vs expected, 896 games, 3-patch window 26.16-26.18.
  7. Qiyana Mid - Low Elo data: Vayne ADC vs Qiyana Mid, 42.5% observed win rate, -3.3 percentage points vs expected, 729 games, 3-patch window 26.16-26.18.
  8. Pantheon Top - Low Elo data: Vayne ADC vs Pantheon Top, 45.1% observed win rate, -3.2 percentage points vs expected, 1,117 games, 3-patch window 26.16-26.18.
  9. Viego Jungle - Low Elo data: Vayne Top vs Viego Jungle, 44.5% observed win rate, -3.1 percentage points vs expected, 1,777 games, 3-patch window 26.16-26.18.
  10. Gwen Mid - Low Elo data: Vayne ADC vs Gwen Mid, 49.1% observed win rate, -3.0 percentage points vs expected, 532 games, 3-patch window 26.16-26.18.

Top 10 High Elo Vayne strongest synergies

  1. Veigar Mid - High Elo data: Vayne ADC vs Veigar Mid, 56.3% observed win rate, +8.5 percentage points vs expected, 526 games, 3-patch window 26.16-26.18.
  2. Zac Jungle - High Elo data: Vayne ADC vs Zac Jungle, 54.3% observed win rate, +4.8 percentage points vs expected, 512 games, 3-patch window 26.16-26.18.
  3. Naafiri Jungle - High Elo data: Vayne ADC vs Naafiri Jungle, 51.5% observed win rate, +4.1 percentage points vs expected, 509 games, 3-patch window 26.16-26.18.
  4. Gnar Top - High Elo data: Vayne ADC vs Gnar Top, 51.1% observed win rate, +3.9 percentage points vs expected, 556 games, 3-patch window 26.16-26.18.
  5. Galio Mid - High Elo data: Vayne Top vs Galio Mid, 52.1% observed win rate, +3.7 percentage points vs expected, 655 games, 3-patch window 26.16-26.18.
  6. Janna Support - High Elo data: Vayne Top vs Janna Support, 53.4% observed win rate, +3.5 percentage points vs expected, 513 games, 3-patch window 26.16-26.18.
  7. Kha'Zix Jungle - High Elo data: Vayne Top vs Kha'Zix Jungle, 51.6% observed win rate, +2.9 percentage points vs expected, 626 games, 3-patch window 26.16-26.18.
  8. Vi Jungle - High Elo data: Vayne ADC vs Vi Jungle, 49.8% observed win rate, +2.8 percentage points vs expected, 610 games, 3-patch window 26.16-26.18.
  9. Talon Jungle - High Elo data: Vayne Top vs Talon Jungle, 53.0% observed win rate, +2.6 percentage points vs expected, 762 games, 3-patch window 26.16-26.18.
  10. Viktor Mid - High Elo data: Vayne Top vs Viktor Mid, 51.2% observed win rate, +2.6 percentage points vs expected, 1,001 games, 3-patch window 26.16-26.18.

Top 10 High Elo Vayne weakest synergies

  1. Thresh Support - High Elo data: Vayne ADC vs Thresh Support, 45.6% observed win rate, -4.4 percentage points vs expected, 1,972 games, 3-patch window 26.16-26.18.
  2. Yone Mid - High Elo data: Vayne Top vs Yone Mid, 44.0% observed win rate, -3.7 percentage points vs expected, 680 games, 3-patch window 26.16-26.18.
  3. Jayce Top - High Elo data: Vayne ADC vs Jayce Top, 42.3% observed win rate, -3.5 percentage points vs expected, 702 games, 3-patch window 26.16-26.18.
  4. Zed Mid - High Elo data: Vayne Top vs Zed Mid, 45.7% observed win rate, -3.2 percentage points vs expected, 810 games, 3-patch window 26.16-26.18.
  5. Morgana Support - High Elo data: Vayne ADC vs Morgana Support, 44.5% observed win rate, -3.1 percentage points vs expected, 532 games, 3-patch window 26.16-26.18.
  6. Kassadin Mid - High Elo data: Vayne ADC vs Kassadin Mid, 45.3% observed win rate, -3.1 percentage points vs expected, 570 games, 3-patch window 26.16-26.18.
  7. Kayn Jungle - High Elo data: Vayne ADC vs Kayn Jungle, 45.0% observed win rate, -2.9 percentage points vs expected, 1,099 games, 3-patch window 26.16-26.18.
  8. Darius Top - High Elo data: Vayne ADC vs Darius Top, 45.3% observed win rate, -2.9 percentage points vs expected, 983 games, 3-patch window 26.16-26.18.
  9. Viktor ADC - High Elo data: Vayne Top vs Viktor ADC, 47.7% observed win rate, -2.8 percentage points vs expected, 732 games, 3-patch window 26.16-26.18.
  10. Yasuo Top - High Elo data: Vayne ADC vs Yasuo Top, 44.5% observed win rate, -2.6 percentage points vs expected, 512 games, 3-patch window 26.16-26.18.