Best Vayne Synergies

The best partner with Vayne is Yuumi Support. The pair wins 50.7% across 5,576 games, 3.0 points more than the two champions' own win rates predict. Nami Support (+1.8 over 6,037 games) and Milio Support (+1.8 over 4,877 games) also over-perform. Based on Low Elo Ranked Solo/Duo games, patches 26.20-26.22. These are observed associations, not guaranteed outcomes. The weakest listed synergies for Vayne are Poppy Support, Nautilus Support, Rell Support, Blitzcrank Support, Leona Support, Tahm Kench Support, Yasuo Mid, Pantheon Support, Samira ADC, and Thresh Support. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Updated 2026-11-15. Data is current for LoL patch 26.22 (all regions, low elo and high elo).

Top 10 Low Elo Vayne strongest synergies

  1. Yuumi Support - 50.7% win rate with Vayne ADC (+3.0 points vs expected), 5,576 games.
  2. Nami Support - 53.4% win rate with Vayne ADC (+1.8 points vs expected), 6,037 games.
  3. Milio Support - 52.6% win rate with Vayne ADC (+1.8 points vs expected), 4,877 games.
  4. Soraka Support - 52.2% win rate with Vayne ADC (+1.5 points vs expected), 4,779 games.
  5. Lulu Support - 49.9% win rate with Vayne ADC (+1.3 points vs expected), 11,792 games.
  6. Brand Support - 51.2% win rate with Vayne ADC (+1.3 points vs expected), 3,310 games.
  7. Zilean Support - 53.7% win rate with Vayne ADC (+1.2 points vs expected), 1,741 games.
  8. Seraphine Support - 51.8% win rate with Vayne ADC (+1.1 points vs expected), 6,639 games.
  9. Xerath Support - 49.9% win rate with Vayne ADC (+0.8 points vs expected), 2,221 games.
  10. Karma Support - 49.6% win rate with Vayne ADC (+0.8 points vs expected), 3,659 games.

Top 10 Low Elo Vayne weakest synergies

  1. Poppy Support - 44.3% win rate with Vayne ADC (-2.1 points vs expected), 1,382 games.
  2. Nautilus Support - 46.8% win rate with Vayne ADC (-1.9 points vs expected), 6,862 games.
  3. Rell Support - 48.8% win rate with Vayne ADC (-1.6 points vs expected), 1,915 games.
  4. Blitzcrank Support - 48.5% win rate with Vayne ADC (-1.3 points vs expected), 5,385 games.
  5. Leona Support - 49.9% win rate with Vayne ADC (-1.3 points vs expected), 6,770 games.
  6. Tahm Kench Support - 47.7% win rate with Vayne ADC (-1.1 points vs expected), 2,964 games.
  7. Yasuo Mid - 47.8% win rate with Vayne Top (-1.1 points vs expected), 2,618 games.
  8. Pantheon Support - 45.7% win rate with Vayne ADC (-1.1 points vs expected), 3,213 games.
  9. Samira ADC - 45.4% win rate with Vayne Top (-1.0 points vs expected), 1,157 games.
  10. Thresh Support - 49.0% win rate with Vayne ADC (-1.0 points vs expected), 8,866 games.

Top 10 High Elo Vayne strongest synergies

  1. Soraka Support - 52.6% win rate with Vayne ADC (+2.8 points vs expected), 2,658 games.
  2. Seraphine Support - 52.1% win rate with Vayne ADC (+2.2 points vs expected), 1,669 games.
  3. Milio Support - 51.0% win rate with Vayne ADC (+2.1 points vs expected), 3,035 games.
  4. Nami Support - 51.6% win rate with Vayne ADC (+1.8 points vs expected), 3,654 games.
  5. Lux Support - 49.3% win rate with Vayne ADC (+1.7 points vs expected), 1,063 games.
  6. Yuumi Support - 47.8% win rate with Vayne ADC (+1.5 points vs expected), 2,756 games.
  7. Zilean Support - 50.3% win rate with Vayne ADC (+0.8 points vs expected), 1,284 games.
  8. Karma Support - 47.5% win rate with Vayne ADC (+0.7 points vs expected), 2,734 games.
  9. Akali Top - 48.3% win rate with Vayne ADC (+0.5 points vs expected), 1,140 games.
  10. Syndra Mid - 47.1% win rate with Vayne Top (+0.5 points vs expected), 1,446 games.

Top 10 High Elo Vayne weakest synergies

  1. Nautilus Support - 44.8% win rate with Vayne ADC (-2.3 points vs expected), 2,113 games.
  2. Rakan Support - 45.7% win rate with Vayne ADC (-1.8 points vs expected), 1,068 games.
  3. Leona Support - 48.1% win rate with Vayne ADC (-1.5 points vs expected), 1,897 games.
  4. Senna Support - 47.7% win rate with Vayne ADC (-1.3 points vs expected), 1,490 games.
  5. Alistar Support - 49.8% win rate with Vayne ADC (-0.7 points vs expected), 1,866 games.
  6. Yone Mid - 46.9% win rate with Vayne Top (-0.6 points vs expected), 1,156 games.
  7. Yasuo Mid - 47.4% win rate with Vayne Top (-0.6 points vs expected), 1,150 games.
  8. Yone Top - 47.6% win rate with Vayne ADC (-0.6 points vs expected), 2,389 games.
  9. Zed Mid - 47.0% win rate with Vayne Top (-0.6 points vs expected), 1,095 games.
  10. Blitzcrank Support - 48.5% win rate with Vayne ADC (-0.6 points vs expected), 2,150 games.

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 1,000 games.

Read the full methodology for the model and guidance on interpreting these results.