Best Vayne Synergies

Use RiftMind to compare Vayne synergies, duo win rates, synergy deltas, sample sizes, and role-specific partner picks for low and high Elo League of Legends team comps.

Updated 2026-06-12. Data is current for LoL patch 26.12 (all regions, low elo and high elo).

Top 10 Low Elo Vayne synergies

Aurelion Sol Mid - Low Elo data: Vayne ADC vs Aurelion Sol Mid, 55.4% observed win rate, +4.8 percentage points vs expected, 664 games, 3-patch window 26.10-26.12.
Janna Support - Low Elo data: Vayne ADC vs Janna Support, 55.8% observed win rate, +4.5 percentage points vs expected, 737 games, 3-patch window 26.10-26.12.
Xin Zhao Jungle - Low Elo data: Vayne Top vs Xin Zhao Jungle, 54.1% observed win rate, +4.4 percentage points vs expected, 785 games, 3-patch window 26.10-26.12.
Urgot Top - Low Elo data: Vayne ADC vs Urgot Top, 53.8% observed win rate, +3.3 percentage points vs expected, 766 games, 3-patch window 26.10-26.12.
Varus ADC - Low Elo data: Vayne Top vs Varus ADC, 50.7% observed win rate, +3.3 percentage points vs expected, 756 games, 3-patch window 26.10-26.12.
Aurora Mid - Low Elo data: Vayne ADC vs Aurora Mid, 52.7% observed win rate, +3.2 percentage points vs expected, 632 games, 3-patch window 26.10-26.12.
Twitch ADC - Low Elo data: Vayne Top vs Twitch ADC, 53.5% observed win rate, +3.1 percentage points vs expected, 666 games, 3-patch window 26.10-26.12.
Sion Top - Low Elo data: Vayne ADC vs Sion Top, 54.0% observed win rate, +3.1 percentage points vs expected, 1,238 games, 3-patch window 26.10-26.12.
Orianna Mid - Low Elo data: Vayne ADC vs Orianna Mid, 49.9% observed win rate, +3.0 percentage points vs expected, 711 games, 3-patch window 26.10-26.12.
Udyr Jungle - Low Elo data: Vayne ADC vs Udyr Jungle, 53.0% observed win rate, +2.8 percentage points vs expected, 540 games, 3-patch window 26.10-26.12.

Top 10 High Elo Vayne synergies

Jax Top - High Elo data: Vayne ADC vs Jax Top, 54.3% observed win rate, +5.0 percentage points vs expected, 530 games, 3-patch window 26.10-26.12.
Nocturne Jungle - High Elo data: Vayne Top vs Nocturne Jungle, 55.4% observed win rate, +4.6 percentage points vs expected, 569 games, 3-patch window 26.10-26.12.
Senna ADC - High Elo data: Vayne Top vs Senna ADC, 57.0% observed win rate, +4.1 percentage points vs expected, 619 games, 3-patch window 26.10-26.12.
Lissandra Mid - High Elo data: Vayne ADC vs Lissandra Mid, 54.2% observed win rate, +3.6 percentage points vs expected, 613 games, 3-patch window 26.10-26.12.
Pyke Support - High Elo data: Vayne ADC vs Pyke Support, 52.8% observed win rate, +3.2 percentage points vs expected, 691 games, 3-patch window 26.10-26.12.
Viktor Mid - High Elo data: Vayne ADC vs Viktor Mid, 51.5% observed win rate, +2.6 percentage points vs expected, 1,005 games, 3-patch window 26.10-26.12.
Sion Top - High Elo data: Vayne ADC vs Sion Top, 52.0% observed win rate, +2.5 percentage points vs expected, 619 games, 3-patch window 26.10-26.12.
Gangplank Top - High Elo data: Vayne ADC vs Gangplank Top, 52.9% observed win rate, +2.5 percentage points vs expected, 609 games, 3-patch window 26.10-26.12.
Shen Top - High Elo data: Vayne ADC vs Shen Top, 52.9% observed win rate, +2.3 percentage points vs expected, 571 games, 3-patch window 26.10-26.12.
Yuumi Support - High Elo data: Vayne ADC vs Yuumi Support, 48.3% observed win rate, +2.2 percentage points vs expected, 830 games, 3-patch window 26.10-26.12.