Yone & Ziggs Synergy
Yone Mid and Ziggs ADC win 56.0% of 3,098 Low Elo games together, +2.2 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why this duo works
Fate Sealed(R) pulls the enemies it hits together, giving Ziggs a concentrated target for the high-damage center of Mega Inferno Bomb(R). Players discussing a Yone–Ziggs teamfight specifically credited Ziggs's centered ultimate for much of the follow-up damage.
Playing the duo
Fate Sealed(R) gathers enemies it hits near Yone, while Mega Inferno Bomb(R) deals more damage in its center; a centered Ziggs ultimate can punish a group Yone has pulled together.
How to play as Yone
Call your Fate Sealed(R) before committing so Ziggs can place Mega Inferno Bomb(R) on the group you pull together; the follow-up is strongest when several enemies are caught in Ziggs's center.
How to play as Ziggs
Wait for Yone's Fate Sealed(R) to pull enemies together, then center Mega Inferno Bomb(R) on the landing area; players watching a Yone–Ziggs fight credited Ziggs's centered ultimate for most of the damage.
Sources
These notes come from leagueoflegends.com and r/leagueoflegends, checked against the champions' abilities.