Karma vs Nautilus Support Matchup
Karma Support wins 46.5% of 4,016 Low Elo games against Nautilus Support, -2.3 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Nautilus is favored
Nautilus can turn an early Dredge Line(Q) hit into a root with Staggering Blow(P), which is especially threatening before Karma has Inspire(E) available to shield and speed herself away. Karma can blunt an engage with Focused Resolve(W) or her shield, but one early catch can snowball the lane.
Measured in High Elo: Nautilus wins 2.2pp more often than expected over 3,082 games.
How to play as Karma
Keep minions between you and Nautilus while his hook is ready, and hold W or E for his approach instead of spending both to poke.
If Nautilus starts running at you, use W before he reaches you; if his hook misses, use that cooldown window to trade back.
Inspire(E) gives Karma a shield and movement speed, while Focused Resolve(W) can root Nautilus if he stays close long enough.
How to play as Nautilus
Look for an early hook when Karma steps beyond her minions; a catch can force Flash or start a snowball before she has her full defensive tools.
Dredge Line(Q) pulls Karma into range for Staggering Blow(P), giving Nautilus a fast follow-up root if the hook lands.
Sources
These notes come from r/karmamains, checked against the champions' abilities.