Karma vs Zyra Support Matchup
Karma Support wins 49.2% of 1,653 Low Elo games against Zyra Support, +0.7 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
How to play as Karma
Keep a sideways angle and use Inspire(E)'s speed to dodge Grasping Roots(E). Karma mains report that Zyra's slower skillshots are manageable when Karma keeps moving, and a missed root gives you a safer window to poke back.
Do not walk through Zyra's seed-grown plants just to force a Focused Resolve(W) tether; stay at Inner Flame(Q) range and commit only after her root or Stranglethorns(R) is spent. (Unverified: no source confirms this note.)
Zyra's Grasping Roots(E) travels in a line and roots enemies it catches, while Karma's Inspire(E) speeds up its target; lateral movement can make it harder for Zyra to land the root and set up her plants.
Sources
These notes come from r/karmamains, checked against the champions' abilities.