Vex vs LeBlanc Mid Matchup
Vex Mid wins 56.3% of 2,837 Low Elo games against LeBlanc Mid, +3.7 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why Vex is favored
Vex's Doom 'n Gloom (Vex P) marks nearby enemy dashes and empowers her next ability to fear and interrupt them, directly punishing the Distortion (LeBlanc W) LeBlanc relies on to enter and exit trades. Holding that fear lets Vex deny LeBlanc's all-in while maintaining pressure, which fits Vex's advantage in both rank scopes.
Measured in High Elo: Vex wins 2.9pp more often than expected over 1,297 games.
How to play as Vex
Hold the fear from Doom 'n Gloom (Vex P) and Personal Space (Vex W) for LeBlanc's Distortion (LeBlanc W) instead of spending them on a speculative long-range spell; the fear can interrupt her dash and W softens her burst.
Doom 'n Gloom (Vex P) marks nearby enemies when they dash and empowers Vex's next basic ability to fear and interrupt dashes, so Distortion (LeBlanc W) gives Vex both a mark and a way to stop the entry.
Personal Space (Vex W) shields Vex while damaging nearby enemies, so it protects her from the close-range burst when LeBlanc uses Distortion (LeBlanc W) to reach her.
How to play as LeBlanc
Do not Distortion (LeBlanc W) into Vex while Doom 'n Gloom (Vex P) is ready; use Sigil of Malice (LeBlanc Q) and Ethereal Chains (LeBlanc E) to trade from range, then commit after Vex spends her fear.
Sources
These notes come from r/vexmains and r/LeBlancMains, checked against the champions' abilities.