Best Zoe Mid Synergies

The best partner with Zoe Mid is Senna Support. The pair wins 52.9% across 2,292 games, 0.8 points more than the two champions' own win rates predict. Vel'Koz Support (+0.7 over 1,334 games) and Seraphine Support (+0.5 over 3,934 games) also over-perform. Shyvana Jungle has the highest raw win rate (53.8%) among well-sampled pairs, but that is about what its own strength predicts (52.0% expected). Based on Low Elo Ranked Solo/Duo games, patches 26.20-26.22. These are observed associations, not guaranteed outcomes. The weakest listed synergies for Zoe Mid are Leona Support, Nautilus Support, Tahm Kench Support, Pyke Support, Sylas Jungle, Blitzcrank Support, Alistar Support, Teemo Top, Lillia Jungle, and Amumu Jungle. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Updated 2026-11-15. Data is current for LoL patch 26.22 (all regions, low elo and high elo).

Zoe Mid duo tips

  1. Zoe & Lucian - Zoe's Sleepy Trouble Bubble(E) puts its target to sleep, and the first damage that wakes them is doubled up to a cap. While the target is immobilized, Lucian's Lightslinger(P) also primes his next two attacks for bonus magic damage.

Top 10 Low Elo Zoe Mid all-role strongest synergies

  1. Senna Support - 52.9% win rate with Zoe Mid (+0.8 points vs expected), 2,292 games.
  2. Vel'Koz Support - 50.4% win rate with Zoe Mid (+0.7 points vs expected), 1,334 games.
  3. Seraphine Support - 51.8% win rate with Zoe Mid (+0.5 points vs expected), 3,934 games.
  4. Aphelios ADC - 51.8% win rate with Zoe Mid (+0.4 points vs expected), 2,729 games.
  5. Brand Support - 47.9% win rate with Zoe Mid (+0.4 points vs expected), 1,435 games.
  6. Kha'Zix Jungle - 49.6% win rate with Zoe Mid (+0.4 points vs expected), 2,172 games.
  7. Soraka Support - 52.6% win rate with Zoe Mid (+0.4 points vs expected), 1,783 games.
  8. Lulu Support - 49.6% win rate with Zoe Mid (+0.4 points vs expected), 3,580 games.
  9. Nami Support - 52.6% win rate with Zoe Mid (+0.4 points vs expected), 2,665 games.
  10. Naafiri Jungle - 51.0% win rate with Zoe Mid (+0.4 points vs expected), 1,239 games.

Top 10 Low Elo Zoe Mid all-role weakest synergies

  1. Leona Support - 48.8% win rate with Zoe Mid (-0.7 points vs expected), 4,033 games.
  2. Nautilus Support - 47.5% win rate with Zoe Mid (-0.6 points vs expected), 4,555 games.
  3. Tahm Kench Support - 50.0% win rate with Zoe Mid (-0.5 points vs expected), 1,447 games.
  4. Pyke Support - 47.7% win rate with Zoe Mid (-0.5 points vs expected), 2,436 games.
  5. Sylas Jungle - 45.2% win rate with Zoe Mid (-0.4 points vs expected), 2,093 games.
  6. Blitzcrank Support - 49.4% win rate with Zoe Mid (-0.4 points vs expected), 3,016 games.
  7. Alistar Support - 49.5% win rate with Zoe Mid (-0.4 points vs expected), 1,900 games.
  8. Teemo Top - 50.3% win rate with Zoe Mid (-0.3 points vs expected), 2,367 games.
  9. Lillia Jungle - 50.8% win rate with Zoe Mid (-0.3 points vs expected), 1,880 games.
  10. Amumu Jungle - 49.4% win rate with Zoe Mid (-0.3 points vs expected), 1,357 games.

Top 10 High Elo Zoe Mid all-role strongest synergies

  1. Samira ADC - 51.2% win rate with Zoe Mid (+0.4 points vs expected), 1,173 games.
  2. Kai'Sa ADC - 51.9% win rate with Zoe Mid (+0.3 points vs expected), 8,352 games.
  3. Jhin ADC - 52.0% win rate with Zoe Mid (+0.3 points vs expected), 7,844 games.
  4. Tristana ADC - 52.0% win rate with Zoe Mid (+0.3 points vs expected), 3,361 games.
  5. Draven ADC - 51.5% win rate with Zoe Mid (+0.3 points vs expected), 1,724 games.
  6. Ambessa Top - 52.4% win rate with Zoe Mid (+0.2 points vs expected), 2,082 games.
  7. Corki ADC - 55.3% win rate with Zoe Mid (+0.2 points vs expected), 1,298 games.
  8. Naafiri Jungle - 53.1% win rate with Zoe Mid (+0.2 points vs expected), 1,485 games.
  9. Soraka Support - 53.1% win rate with Zoe Mid (+0.2 points vs expected), 1,967 games.
  10. Twitch ADC - 53.7% win rate with Zoe Mid (+0.2 points vs expected), 1,759 games.

Top 10 High Elo Zoe Mid all-role weakest synergies

  1. Leona Support - 50.7% win rate with Zoe Mid (-0.5 points vs expected), 3,021 games.
  2. Smolder ADC - 49.8% win rate with Zoe Mid (-0.3 points vs expected), 1,460 games.
  3. Varus ADC - 50.3% win rate with Zoe Mid (-0.3 points vs expected), 1,355 games.
  4. Pyke Support - 50.4% win rate with Zoe Mid (-0.3 points vs expected), 2,337 games.
  5. Ashe ADC - 49.9% win rate with Zoe Mid (-0.3 points vs expected), 1,943 games.
  6. Aatrox Top - 49.5% win rate with Zoe Mid (-0.2 points vs expected), 2,850 games.
  7. Vi Jungle - 47.2% win rate with Zoe Mid (-0.2 points vs expected), 1,707 games.
  8. Nautilus Support - 50.3% win rate with Zoe Mid (-0.2 points vs expected), 4,574 games.
  9. Lillia Jungle - 51.3% win rate with Zoe Mid (-0.2 points vs expected), 1,314 games.
  10. Elise Jungle - 51.1% win rate with Zoe Mid (-0.2 points vs expected), 1,090 games.

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 1,000 games.

Read the full methodology for the model and guidance on interpreting these results.