Best Karthus ADC Synergies

Compare Karthus ADC strongest and weakest synergies by duo win rate, expected win rate, delta, sample size, and allied role for team comp planning.

Updated 2026-09-20. Data is current for LoL patch 26.18 (all regions, low elo and high elo).

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 500 games.

Read the full methodology for the model and guidance on interpreting these results.

Summary

High Elo data lists Nami Support as the strongest Support duo partners for Karthus ADC. The weakest listed synergies for Karthus ADC are Leona Support and Nautilus Support. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Detailed info:

Top 1 High Elo Karthus ADC bot-lane duo synergies with Support

  1. Nami Support - High Elo data: Karthus ADC vs Nami Support, 55.2% observed win rate, +0.8 percentage points vs expected, 782 games, 3-patch window 26.16-26.18.

Top 2 High Elo Karthus ADC weakest bot-lane duo synergies with Support

  1. Leona Support - High Elo data: Karthus ADC vs Leona Support, 54.7% observed win rate, -1.2 percentage points vs expected, 601 games, 3-patch window 26.16-26.18.
  2. Nautilus Support - High Elo data: Karthus ADC vs Nautilus Support, 53.7% observed win rate, -0.4 percentage points vs expected, 654 games, 3-patch window 26.16-26.18.

Top 5 High Elo Karthus ADC all-role strongest synergies

  1. Graves Jungle - High Elo data: Karthus ADC vs Graves Jungle, 57.9% observed win rate, +3.9 percentage points vs expected, 556 games, 3-patch window 26.16-26.18.
  2. Yasuo Mid - High Elo data: Karthus ADC vs Yasuo Mid, 56.5% observed win rate, +3.2 percentage points vs expected, 520 games, 3-patch window 26.16-26.18.
  3. Zed Mid - High Elo data: Karthus ADC vs Zed Mid, 55.9% observed win rate, +1.5 percentage points vs expected, 556 games, 3-patch window 26.16-26.18.
  4. Nami Support - High Elo data: Karthus ADC vs Nami Support, 55.2% observed win rate, +0.8 percentage points vs expected, 782 games, 3-patch window 26.16-26.18.
  5. Lee Sin Jungle - High Elo data: Karthus ADC vs Lee Sin Jungle, 54.2% observed win rate, +0.5 percentage points vs expected, 614 games, 3-patch window 26.16-26.18.

Top 2 High Elo Karthus ADC all-role weakest synergies

  1. Leona Support - High Elo data: Karthus ADC vs Leona Support, 54.7% observed win rate, -1.2 percentage points vs expected, 601 games, 3-patch window 26.16-26.18.
  2. Nautilus Support - High Elo data: Karthus ADC vs Nautilus Support, 53.7% observed win rate, -0.4 percentage points vs expected, 654 games, 3-patch window 26.16-26.18.