Vayne & Nami Synergy
Vayne ADC and Nami Support win 52.9% of 3,098 Low Elo games together, +1.7 points vs expected, 2-patch window 26.19-26.20.
Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.
Why this duo works
Nami's Tidecaller's Blessing(E) adds damage and a slow to Vayne's attacks, strengthening the repeated-hit pattern that triggers Silver Bolts(W); Vayne players specifically call out the E and W interaction. Nami's healing also helps Vayne through her rough early lane so she can scale.
Playing the duo
Coordinate Tidecaller's Blessing(E) with Vayne's attack sequence on one target so its damage and slow overlap with her Silver Bolts(W) hits.
Tidecaller's Blessing(E) adds magic damage and a slow to Vayne's attacks, while Silver Bolts(W) deals max-health true damage on the third consecutive hit; Vayne players specifically call out combining Nami's E with the W passive.
How to play as Vayne
Use Nami's Ebb and Flow(W) to recover after poke instead of forcing a losing trade; Vayne mains describe enchanter sustain as a way to get through her vulnerable early lane and scale.
Ebb and Flow(W) heals Vayne, which helps cover her rough early lane; Vayne players describe sustaining enchanters as a way to enable her to scale.
Sources
These notes come from r/vaynemains, checked against the champions' abilities.