Best Vayne ADC Synergies

The best Support with Vayne ADC is Yuumi. The pair wins 50.7% across 5,576 games, 3.0 points more than the two champions' own win rates predict. Nami (+1.8 over 6,037 games) and Milio (+1.8 over 4,877 games) also over-perform. Based on Low Elo Ranked Solo/Duo games, patches 26.20-26.22. These are observed associations, not guaranteed outcomes. The weakest listed synergies for Vayne ADC are Poppy Support, Nautilus Support, Rell Support, Blitzcrank Support, Leona Support, Tahm Kench Support, Pantheon Support, Thresh Support, Alistar Support, and Pyke Support. The detailed info below lists each partner with observed win rate, expected win rate delta, sample size, rank scope, and patch window.

Updated 2026-11-15. Data is current for LoL patch 26.22 (all regions, low elo and high elo).

Vayne ADC duo tips

  1. Vayne & Nami - Nami's Tidecaller's Blessing(E) adds damage and a slow to Vayne's attacks, strengthening the repeated-hit pattern that triggers Silver Bolts(W); Vayne players specifically call out the E and W interaction. Nami's healing also helps Vayne through her rough early lane so she can scale.
  2. Vayne & Yuumi - Vayne's Tumble(Q) and Final Hour(R) make her hard to pin down, while Yuumi can follow her, add an on-hit effect, and shield and speed her up with Zoomies(E). That combination helps Vayne keep attacking and repositioning through a long fight.
  3. Vayne & Blitzcrank - Blitzcrank's hook and knock-up create time for Vayne to land repeated Silver Bolts(W) attacks; Vayne players say Blitz can help her survive the weak early lane and get room to auto.
  4. Fizz & Vayne - Chum the Waters (Fizz R) slows and then knocks up its target, giving Vayne (Vayne W) a brief, more predictable window to stack Silver Bolts. Vayne's sustained physical damage also complements Fizz's magic burst when they focus the same target.
  5. Vayne & Milio - Milio gives Vayne the range she lacks and pairs it with a shield, movement speed and emergency cleanse. That lets Vayne take safer extended trades and survive crowd control while she builds into a stronger carry.
  6. Lillia & Vayne - Lillia's area sleep gives Vayne a clear target to follow up on, and waking that target triggers Lillia's bonus damage while Vayne continues her sustained attacks. The pair works best when Lillia's Dream Dust has landed before she casts her ultimate.
  7. Illaoi & Vayne - Leap of Faith (R) creates an extra Tentacle for each enemy champion Illaoi hits, while Silver Bolts (W) gives Vayne percentage max-health true damage on repeated hits.

Top 10 Low Elo Vayne ADC bot-lane duo synergies with Support

  1. Yuumi Support - 50.7% win rate with Vayne ADC (+3.0 points vs expected), 5,576 games.
  2. Nami Support - 53.4% win rate with Vayne ADC (+1.8 points vs expected), 6,037 games.
  3. Milio Support - 52.6% win rate with Vayne ADC (+1.8 points vs expected), 4,877 games.
  4. Soraka Support - 52.2% win rate with Vayne ADC (+1.5 points vs expected), 4,779 games.
  5. Lulu Support - 49.9% win rate with Vayne ADC (+1.3 points vs expected), 11,792 games.
  6. Brand Support - 51.2% win rate with Vayne ADC (+1.3 points vs expected), 3,310 games.
  7. Zilean Support - 53.7% win rate with Vayne ADC (+1.2 points vs expected), 1,741 games.
  8. Seraphine Support - 51.8% win rate with Vayne ADC (+1.1 points vs expected), 6,639 games.
  9. Xerath Support - 49.9% win rate with Vayne ADC (+0.8 points vs expected), 2,221 games.
  10. Karma Support - 49.6% win rate with Vayne ADC (+0.8 points vs expected), 3,659 games.

Top 10 Low Elo Vayne ADC weakest bot-lane duo synergies with Support

  1. Poppy Support - 44.3% win rate with Vayne ADC (-2.1 points vs expected), 1,382 games.
  2. Nautilus Support - 46.8% win rate with Vayne ADC (-1.9 points vs expected), 6,862 games.
  3. Rell Support - 48.8% win rate with Vayne ADC (-1.6 points vs expected), 1,915 games.
  4. Blitzcrank Support - 48.5% win rate with Vayne ADC (-1.3 points vs expected), 5,385 games.
  5. Leona Support - 49.9% win rate with Vayne ADC (-1.3 points vs expected), 6,770 games.
  6. Tahm Kench Support - 47.7% win rate with Vayne ADC (-1.1 points vs expected), 2,964 games.
  7. Pantheon Support - 45.7% win rate with Vayne ADC (-1.1 points vs expected), 3,213 games.
  8. Thresh Support - 49.0% win rate with Vayne ADC (-1.0 points vs expected), 8,866 games.
  9. Alistar Support - 49.4% win rate with Vayne ADC (-0.8 points vs expected), 3,077 games.
  10. Pyke Support - 46.5% win rate with Vayne ADC (-0.8 points vs expected), 4,316 games.

Top 10 Low Elo Vayne ADC all-role strongest synergies

  1. Yuumi Support - 50.7% win rate with Vayne ADC (+3.0 points vs expected), 5,576 games.
  2. Nami Support - 53.4% win rate with Vayne ADC (+1.8 points vs expected), 6,037 games.
  3. Milio Support - 52.6% win rate with Vayne ADC (+1.8 points vs expected), 4,877 games.
  4. Soraka Support - 52.2% win rate with Vayne ADC (+1.5 points vs expected), 4,779 games.
  5. Lulu Support - 49.9% win rate with Vayne ADC (+1.3 points vs expected), 11,792 games.
  6. Brand Support - 51.2% win rate with Vayne ADC (+1.3 points vs expected), 3,310 games.
  7. Zilean Support - 53.7% win rate with Vayne ADC (+1.2 points vs expected), 1,741 games.
  8. Seraphine Support - 51.8% win rate with Vayne ADC (+1.1 points vs expected), 6,639 games.
  9. Xerath Support - 49.9% win rate with Vayne ADC (+0.8 points vs expected), 2,221 games.
  10. Karma Support - 49.6% win rate with Vayne ADC (+0.8 points vs expected), 3,659 games.

Top 10 Low Elo Vayne ADC all-role weakest synergies

  1. Poppy Support - 44.3% win rate with Vayne ADC (-2.1 points vs expected), 1,382 games.
  2. Nautilus Support - 46.8% win rate with Vayne ADC (-1.9 points vs expected), 6,862 games.
  3. Rell Support - 48.8% win rate with Vayne ADC (-1.6 points vs expected), 1,915 games.
  4. Blitzcrank Support - 48.5% win rate with Vayne ADC (-1.3 points vs expected), 5,385 games.
  5. Leona Support - 49.9% win rate with Vayne ADC (-1.3 points vs expected), 6,770 games.
  6. Tahm Kench Support - 47.7% win rate with Vayne ADC (-1.1 points vs expected), 2,964 games.
  7. Pantheon Support - 45.7% win rate with Vayne ADC (-1.1 points vs expected), 3,213 games.
  8. Thresh Support - 49.0% win rate with Vayne ADC (-1.0 points vs expected), 8,866 games.
  9. Alistar Support - 49.4% win rate with Vayne ADC (-0.8 points vs expected), 3,077 games.
  10. Pyke Support - 46.5% win rate with Vayne ADC (-0.8 points vs expected), 4,316 games.

Top 10 High Elo Vayne ADC bot-lane duo synergies with Support

  1. Soraka Support - 52.6% win rate with Vayne ADC (+2.8 points vs expected), 2,658 games.
  2. Seraphine Support - 52.1% win rate with Vayne ADC (+2.2 points vs expected), 1,669 games.
  3. Milio Support - 51.0% win rate with Vayne ADC (+2.1 points vs expected), 3,035 games.
  4. Nami Support - 51.6% win rate with Vayne ADC (+1.8 points vs expected), 3,654 games.
  5. Lux Support - 49.3% win rate with Vayne ADC (+1.7 points vs expected), 1,063 games.
  6. Yuumi Support - 47.8% win rate with Vayne ADC (+1.5 points vs expected), 2,756 games.
  7. Zilean Support - 50.3% win rate with Vayne ADC (+0.8 points vs expected), 1,284 games.
  8. Karma Support - 47.5% win rate with Vayne ADC (+0.7 points vs expected), 2,734 games.
  9. Lulu Support - 48.7% win rate with Vayne ADC (+0.5 points vs expected), 8,820 games.
  10. Janna Support - 50.0% win rate with Vayne ADC (+0.5 points vs expected), 2,818 games.

Top 10 High Elo Vayne ADC weakest bot-lane duo synergies with Support

  1. Nautilus Support - 44.8% win rate with Vayne ADC (-2.3 points vs expected), 2,113 games.
  2. Rakan Support - 45.7% win rate with Vayne ADC (-1.8 points vs expected), 1,068 games.
  3. Leona Support - 48.1% win rate with Vayne ADC (-1.5 points vs expected), 1,897 games.
  4. Senna Support - 47.7% win rate with Vayne ADC (-1.3 points vs expected), 1,490 games.
  5. Alistar Support - 49.8% win rate with Vayne ADC (-0.7 points vs expected), 1,866 games.
  6. Blitzcrank Support - 48.5% win rate with Vayne ADC (-0.6 points vs expected), 2,150 games.
  7. Thresh Support - 50.2% win rate with Vayne ADC (-0.5 points vs expected), 4,404 games.
  8. Bard Support - 46.1% win rate with Vayne ADC (-0.2 points vs expected), 1,239 games.
  9. Pyke Support - 47.5% win rate with Vayne ADC (-0.0 points vs expected), 1,698 games.
  10. Sona Support - 48.6% win rate with Vayne ADC (-0.0 points vs expected), 1,219 games.

Top 10 High Elo Vayne ADC all-role strongest synergies

  1. Soraka Support - 52.6% win rate with Vayne ADC (+2.8 points vs expected), 2,658 games.
  2. Seraphine Support - 52.1% win rate with Vayne ADC (+2.2 points vs expected), 1,669 games.
  3. Milio Support - 51.0% win rate with Vayne ADC (+2.1 points vs expected), 3,035 games.
  4. Nami Support - 51.6% win rate with Vayne ADC (+1.8 points vs expected), 3,654 games.
  5. Lux Support - 49.3% win rate with Vayne ADC (+1.7 points vs expected), 1,063 games.
  6. Yuumi Support - 47.8% win rate with Vayne ADC (+1.5 points vs expected), 2,756 games.
  7. Zilean Support - 50.3% win rate with Vayne ADC (+0.8 points vs expected), 1,284 games.
  8. Karma Support - 47.5% win rate with Vayne ADC (+0.7 points vs expected), 2,734 games.
  9. Akali Top - 48.3% win rate with Vayne ADC (+0.5 points vs expected), 1,140 games.
  10. Lux Mid - 50.6% win rate with Vayne ADC (+0.5 points vs expected), 1,400 games.

Top 10 High Elo Vayne ADC all-role weakest synergies

  1. Nautilus Support - 44.8% win rate with Vayne ADC (-2.3 points vs expected), 2,113 games.
  2. Rakan Support - 45.7% win rate with Vayne ADC (-1.8 points vs expected), 1,068 games.
  3. Leona Support - 48.1% win rate with Vayne ADC (-1.5 points vs expected), 1,897 games.
  4. Senna Support - 47.7% win rate with Vayne ADC (-1.3 points vs expected), 1,490 games.
  5. Alistar Support - 49.8% win rate with Vayne ADC (-0.7 points vs expected), 1,866 games.
  6. Yone Top - 47.6% win rate with Vayne ADC (-0.6 points vs expected), 2,389 games.
  7. Blitzcrank Support - 48.5% win rate with Vayne ADC (-0.6 points vs expected), 2,150 games.
  8. Yasuo Mid - 48.3% win rate with Vayne ADC (-0.6 points vs expected), 2,806 games.
  9. Irelia Top - 46.4% win rate with Vayne ADC (-0.5 points vs expected), 1,437 games.
  10. Thresh Support - 50.2% win rate with Vayne ADC (-0.5 points vs expected), 4,404 games.

How these matchup statistics are calculated

Counter and synergy statistics use Ranked Solo/Duo games, exclude matches shorter than 600 seconds, and group results by patch window, region, rank scope, and champion role.

Pairwise pages use a rolling three-patch window and compare observed win rate with a log-odds expected win rate based on each champion's role-adjusted baseline; listed pairs require at least 1,000 games.

Read the full methodology for the model and guidance on interpreting these results.