Vayne ADC vs Brand Support Matchup

Vayne ADC wins 47.5% of 1,800 Low Elo games against Brand Support, -0.5 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

How to play as Vayne

Hold Tumble (Q) for Brand's Pillar of Flame (W) and dodge sideways; Vayne players recommend saving Q for this rather than using it to step forward.

When Brand has his area spells available, prioritize staying healthy and collecting safe farm instead of forcing a trade; look to fight when your support or jungler creates an opening.

Vayne can use Tumble (Q) to dodge Brand's Pillar of Flame (W), but Brand's other area spells can still punish Vayne if she uses the dash too early.

Sources

These notes come from r/vaynemains, checked against the champions' abilities.