Vayne vs Ezreal ADC Matchup

Vayne ADC wins 56.8% of 3,783 Low Elo games against Ezreal ADC, +2.8 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

Why Vayne is favored

Vayne can use Tumble(Q) to dodge Ezreal's main poke and then stay on him, where Silver Bolts(W) rewards repeated hits in an extended fight. Ezreal's skillshot damage is easier to avoid at close range, so Vayne can turn his poke advantage into a close-range trade on her terms.

Measured in High Elo: Vayne wins 1.6pp more often than expected over 1,032 games.

How to play as Vayne

Keep moving to sidestep Mystic Shot(Q) and the follow-up to Essence Flux(W); use Tumble(Q) to dodge his shots and hold Condemn(E) for when he Arcane Shifts(E) into a wall angle.

Ezreal relies heavily on Mystic Shot(Q) and Essence Flux(W) skillshots for poke, while Tumble(Q) gives Vayne a quick reposition to sidestep them; Condemn(E) can punish him if he Arcane Shifts(E) near a wall.

Silver Bolts(W) deals true damage based on the target's maximum health on every third consecutive attack or ability, rewarding Vayne when she can keep hitting Ezreal.

How to play as Ezreal

Avoid spending Arcane Shift(E) into Condemn(E) range while Vayne can stun you into a wall. Use Mystic Shot(Q) to chip her and hold your escape until she commits to a fight.

Sources

These notes come from r/vaynemains and r/ezrealmains, checked against the champions' abilities.