Vayne ADC vs Pantheon Support Matchup

Vayne ADC wins 49.4% of 1,834 Low Elo games against Pantheon Support, -0.6 points vs expected, 2-patch window 26.19-26.20.

Researched on LoL patch 26.20. Tips are written to hold at any rank; stats come from Low Elo ranked games up to patch 26.20.

How to play as Vayne

Predict Pantheon's Aegis Assault (W) and use Condemn (E) as he commits; reacting after the stun connects is too late to stop the engage.

Stay outside Pantheon's jump range while his stun is ready. If he uses Aegis Assault (W), or spends Aegis Assault (E) to disengage, kite him and punish the cooldown window.

Condemn (E) can knock Pantheon out of his Aegis Assault (W) leap before the point-and-click stun lands, if Vayne predicts the engage.

Sources

These notes come from r/ADCMains, checked against the champions' abilities.